Altamax Caution For Usage

Compatibility and Stability: Intravenous: Cefepime is compatible at concentrations between 1 mg per mL and 40 mg per mL with the following intravenous fluids: 0.9% Sodium Chloride Injection, 5% and 10% Dextrose Injection, M/6 Sodium Lactate Injection, 5% Dextrose and 0.9% Sodium Chloride Injection, and Lactated Ringers and 5% Dextrose Injection. These solutions may be stored up to 24 hours at controlled room temperature 20°-25°C (68°-77°F) or 7 days in refrigerator 2°-8°C (36°-46°F).
Solutions of Cefepime, like those of beta-lactam antibiotics, should not be added to solutions of ampicillin at a concentration greater than 40 mg per mL, and should not be added to metronidazole, vancomycin, gentamicin, tobramycin, netilmicin sulfate, or aminophylline because of potential interaction. However, if concurrent therapy with Cefepime is indicated, each of these antibiotics can be administered separately.
Intramuscular: Cefepime (cefepime hydrochloride) constituted as directed is stable for 24 hours at controlled room temperature 20°-25°C (68°-77°F) or 7 days in refrigerator 2°-8°C (36°-46°F) with the following diluents: Sterile Water for Injection, 0.9% Sodium Chloride Injection, 5% Dextrose Injection, Sterile Bacteriostatic Water for Injection with Parabens or Benzyl Alcohol, or 0.5% or 1% Lidocaine Hydrochloride.
NOTE: Parenteral drugs should be inspected visually for particulate matter before administration.
As with other cephalosporins, the color of Cefepime powder, as well as its solutions, tend to darken depending on storage conditions; however, when stored as recommended, the product potency is not adversely affected.