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Topical application of Trifarotene (Aklief) cream is not expected to affect the circulating concentrations of oral hormonal contraceptives containing ethinyl estradiol and levonorgestrel.
Effect of other medicinal products on Trifarotene (Aklief) cream: No clinical drug-drug interaction studies were performed to assess effects of other drugs on trifarotene systemic levels.
There is no data on the pharmacodynamic interaction potential of trifarotene. Caution should be exercised if cosmetics or acne medications with desquamative, irritant or drying effects are concomitantly used with the medicinal product, as they may produce additive irritant effects.
Model based approach: No clinically significant differences in the pharmacokinetics of trifarotene were predicted when used concomitantly with fluconazole (a moderate CYP2C9 and CYP3A inhibitor).
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