Advantan Special Precautions

Additional, specific therapy is required in bacterially infected skin diseases and/or in fungal infections.
If the skin dries out excessively under protracted use of Methylprednisolone aceponate (Advantan) cream, a switch should be made to one of the formulations with a higher fat content (Methylprednisolone aceponate (Advantan) ointment or Methylprednisolone aceponate (Advantan) fatty ointment).
Care must be taken when using Methylprednisolone aceponate (Advantan) cream, ointment or fatty ointment to avoid contact with the eyes, deep open wounds and mucosae.
No impairment of the adrenocortical function has been observed in children on large area (40-90 % of the skin surface) nonocclusive treatment with Methylprednisolone aceponate (Advantan) 0.1% fatty ointment. After application of Methylprednisolone aceponate (Advantan) 0.1% ointment to 60 % skin surface area under occlusive conditions for 22 hours, suppression of plasma cortisol levels and influence on circadian rhythm was observed in adult healthy volunteers.
Extensive application of topical corticosteroids to large areas of the body or for prolonged periods of time, in particular under occlusion, significantly increases the risk of systemic side effects. Note that diapers can be occlusive. This is especially relevant as Methylprednisolone aceponate (Advantan) cream is also not recommended for use in children under 3 years of age.
As known from systemic corticoids, glaucoma may also develop from using local corticoids (e.g. after large-dosed or extensive application over a prolonged period, occlusive dressing techniques, or application to the skin around the eyes).
Two excipients contained in Methylprednisolone aceponate (Advantan) 0.1% cream (cetostearyl alcohol and butyl hydroxytoluene) may cause local skin reactions (e.g., contact dermatitis). Butyl hydroxytoluene may also cause irritation in the eyes and mucous membranes.
Effects on ability to drive or use machines: No influence on the ability to drive and use machines.