Advantan Adverse Reactions

In clinical studies, most frequently observed side-effects included application site burning and application site pruritus with Methylprednisolone aceponate (Advantan) cream and ointment. For Methylprednisolone aceponate (Advantan) fatty ointment, application site folliculitis and application site burning were observed most frequently.
Frequencies of side-effects observed in clinical studies and given in the tables as follows are defined according to the MedDRA frequency convention: very common (>1/10); common (>1/100, <1/10); uncommon (>1/1,000; <1/100), rare (>1/10,000, <1/1,000); very rare (<1/10,000), not known (cannot be estimated from available data). MedDRA version 12.0 was used for coding.
Methylprednisolone aceponate (Advantan) Cream 0.1%: See Table 1.

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Methylprednisolone aceponate (Advantan) Ointment 0.1%: See Table 2.

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Methylprednisolone aceponate (Advantan) Fatty Ointment 0.1%: See Table 3.

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As with other corticoids for topical application, the following local side-effects may occur: skin atrophy, skin striae, application site folliculitis, hypertrichosis, telangiectasia, perioral dermatitis, skin discoloration, and allergic skin reactions to any of the ingredients of the formulations. Systemic effects due to absorption may occur when topical preparations containing corticoids are applied.