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Local reactions: Redness, warmth, edema, induration with or without tenderness as well as urticaria and rash.
Systemic reactions: Malaise, transient fever, pain, hypotension, nausea and arthralgia may develop in some patients after the injection.
Arthus-type hypersensitivity reactions, characterized by severe local reactions (generally starting 2 to 8 hrs after an injection) may occur, particularly in persons who have received multiple prior booster doses of a Tetanus toxoid-containing vaccine. Rarely anaphylaxis can also occur.
The following neurologic illness have been reported as temporarily associated with tetanus toxoid: neurological complications including cochlear lesion, brachial plexus neuropathies, paralysis of the radial nerve, paralysis of the recurrent nerve, accommodation paresis and EEG disturbances with encephalopathy. There may be a casual relation between Guillain-Barre syndrome (GBS) and vaccines containing tetanus toxoid.
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