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For infections caused by susceptible organisms in lower respiratory tract infection including bronchitis and pneumonia, skin and soft tissue infections, acute otitis media, upper respiratory tract infections including sinusitis and pharyngitis/tonsilitis. (Penicillin is the usual drug of choice in the treatment of Streptococcus pyogenes pharyngitis including the prophylaxis of rheumatic fever. Azithromycin is generally effective in the eradication of streptococci from the oropharynx, however, data establishing the efficacy of azithromycin and the subsequent prevention of rheumatic fever are not available at present).
In sexually transmitted disease in men and women, treatment of uncomplicated genital infections due to Chlamydia trachomatis. Treatment of Chancroid due to H. ducreyi and uncomplicated genital infection due to non-multiresistant Neisseria gonorrhoea, concurrent infection with Treponema pallidum should be excluded.
Either alone or in combination with rifabutin, for prophylaxis against Mycobacterium avium-intracellulare complex (MAC) infection, an opportunistic infection prevalent in patients with advanced HIV.
In combination with ethambutol for the treatment of disseminated MAC (DMAC) infection in patients with advanced HIV infection.
