Zithrolide Dosage/Direction for Use

Adults and Elderly: For the treatment of sexually transmitted diseases (STD) caused by Clamydia trachomatis or susceptible Neisseria gonnorhoea and chancroid due to H. ducreyi, 1 g as a single oral dose. Prophylaxis against MAC infections in patients with HIV infection, 1200 mg once weekly.
For all other indications, the total dosage of 1500 mg should be given as 500 mg daily for 3 days or can be given over 5 days with 500 mg given on day 1, then 250 mg daily on days 2-5.
For the treatment of DMAC infections in patients with advanced HIV infection, the recommended dose is 600 mg once daily. Azithromycin should be administered in combination with other antimycobacterial agents that have shown in vitro activity against MAC, eg, ethambutol at the approved dose.
Children: With a single exception of the treatment of Streptococcal pharyngitis, the total dose in children is 30 mg/kg which should be given as a single daily dose of 10 mg/kg daily for 3 days or as an alternative, given over 5 days with a single dose of 10 mg/kg on 1 day, then 5 mg/kg on days 2-5. Treatment of acute otitis media in children may be given as either a single dose of 30 mg/kg. Zithrolide tablets should only be administered to children weighing >45 kg. Safety and efficacy for the prevention of MAC in children have not been established. Based on paediatric pharmacokinetics data, a dose of 20 mg/kg would be similar to the adult dose of 1200 mg but with a higher maximum plasma concentration (C_max).
Paediatric Streptococci Pharyngitis: Single dose of 10 mg/kg or 20 mg/kg for 3 days has been shown to be effective; however, do not exceed a daily dose of 500 mg.
Special Populations: Renal Impairment: The same dosage in patients with normal renal function maybe used in patients with mild renal impairment (creatinine clearance >40 mL/min). There are no data regarding azithromycin usage in patients with more severe renal impairment.
Hepatic Impairment: The same dosage as in patients with normal hepatic function may be used in patients with mild to moderate hepatic impairment.
Administration: Azithromycin should be administered as a single daily dose. Azithromycin tablet can be taken with food.