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Pregnancy: There is no data on the use of trimetazidine in pregnant women. Studies performed in animals have not revealed direct or indirect harmful effects on reproduction (see Pharmacology: Toxicology: Preclinical safety data under Actions). As a precautionary measure, it is preferable to avoid the use of VASTAREL during pregnancy.
Breast-feeding: It is not known whether trimetazidine/metabolites are excreted in breast milk. A risk to the newborns/infants cannot be excluded. VASTAREL should not be used during breast-feeding.
Fertility: Reproductive toxicity studies have shown no effect on fertility in female and male rats (see Pharmacology: Toxicology: Preclinical safety data under Actions).
