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Contraindicated in patients with severe renal impairment or renal failure, hypernatremia, overt and occult cardiac failure, severe myocardial damage, respiratory alkalosis, hypocalcemia, hypochloremia, hypochlorhydria, Addison's disease, acute dehydration and heat cramps.
Not recommended in concomitant use with hexamine mandelate or hexamine hippurate therapy because acid urine is needed to be activated.
Concomitant use of urinary alkalinisers and quinolone antibiotics should also be avoided because crystalluria may be more likely to occur in alkaline urine.
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