Synvisc/Synvisc-One Dosage/Direction for Use

Dosage Guidelines: The dosage regimen for hylan G-F 20 is dependent on the joint being treated.
Synvisc: Osteoarthritis of the knee: The recommended treatment regimen is three 2 mL injections in the knee, with an interval of 1 week between each injection. To achieve maximum effect, it is essential to administer all three injections. The maximum recommended dosage is six injections within six months, with a minimum of four weeks between treatment regimens.
Osteoarthritis of the hip/ankle/shoulder: The recommended initial treatment regimen is a single 2 mL injection. If however, adequate symptomatic relief is not achieved after this injection, it is recommended to administer a second 2 mL injection. Clinical data have demonstrated that patients benefit from this second injection when administered between 1 and 3 months after the first injection.
Synvisc-One: Osteoarthritis of the knee: The recommended treatment regimen is one 6 mL injection in the knee. The injection may be repeated 6 months after the first injection, if justified by the patient's symptoms.