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If venous or lymphatic stasis is present in the relevant limb, hylan G-F 20 should not be injected into the joint.
Hylan G-F 20 should not be used in infected or severely inflamed joints or in patients having skin diseases or infections in the area of the injection site.
Hylan G-F 20 should not be used in patients with known hypersensitivity (allergy) to hyaluronan (sodium hyaluronate) preparations.
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