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Symptoms and Treatment for Overdosage and Antidote(s): Overdosage with hyoscine butylbromide may cause disorientation, memory disturbances, dizziness, restlessness, hallucinations, or confusion.
Treatment: Empty the stomach by aspiration and lavage. The use of charcoal to prevent absorption, followed by lavage, has been suggested. Give a purgative, such as 30 g of sodium sulphate in 250 ml of water. Physostigmine salicylate has been advocated to control the central and peripheral effects of hyoscine but is not now generally recommended. Excitement may be controlled by diazepam or a short-acting barbiturate. Supportive therapy may require oxygen and assisted respiration, ice bags or alcohol sponges for hyperpyrexia, especially in children, bladder catheterisation, and the administration of fluids.
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