The anticholinergic effect of tricyclic antidepressants, antihistamines, quinidine, amantadine, and disopyramide can potentiate the anticholinergic effect of Hyoscine butylbromide.
Hyoscine butylbromide enhances tachycardic effects of β-adrenergic agents. Dopamine antagonist, eg, metoclopramide, reduces effects of both drugs on GIT.