Prophylaxis of acute organ rejection in de novo renal transplantation in combination w/ ciclosporin & corticosteroid-based immunosuppression in adults & childn; or long-term immunosuppressive triple therapy w/ ciclosporin, corticosteroids & either azathioprine or mycophenolate mofetil in adults.
2 doses: 1st dose w/in 2 hr before transplantation surgery & 2nd dose 4 days after transplantation. Adult & childn ≥35 kg 20 mg/dose; <35 kg 10 mg/dose.
Discontinue use if severe hypersensitivity reactions occur. Increased risk of developing lymphoproliferative disorders & opportunistic infections eg, cytomegalovirus. Not recommended w/ live vaccines for immunosuppressed patients. Women of childbearing potential should use effective contraception for 4 mth after last dose. Pregnancy. Not to be used during lactation & for 4 mth after last dose.
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