Safrosyn S Use In Pregnancy & Lactation

Pregnancy: In view of the known effects of naproxen on the human foetal cardiovascular system (risk of closure of the ductus arteriosus), use in the last trimester of pregnancy is contraindicated. The onset of labour may be delayed and the duration increased with an increased bleeding tendency in both mother and child by naproxen. Therefore, naproxen should not be used during the first two trimesters of pregnancy or labour unless the potential benefit to the patient outweighs the potential risk to the foetus.
Labour and Delivery: Naproxen containing products are not recommended in labour and delivery because, through its prostaglandin synthesis inhibitory effect, naproxen may adversely affect foetal circulation and inhibit uterine contractions, with an increased bleeding tendency in both mother and child.
Lactation: Naproxen can appear in breast milk in very low concentrations. Because of the possible adverse effects of prostaglandin-inhibiting drugs on neonates, the use of naproxen in nursing mothers is not recommended.