Ostenil/Ostenil Mini/Ostenil Plus Mechanism of Action

Pharmacology: Characteristics and mode of action: Synovial fluid, which is viscoelastic due to the presence of hyaluronic acid, is found in all synovial joints, where it ensures normal, painless movement due to its lubricating and shock-absorbing properties. In degenerative joint disorders such as osteoarthritis, the viscoelasticity of the synovial fluid is markedly reduced thereby decreasing its lubricating and shock-absorbing functions. This increases mechanical loading of the joint and cartilage destruction which ultimately results in pain and restricted mobility of the affected joint. Supplementing this synovial fluid with intra-articular injections of highly purified hyaluronic acid can ameliorate the viscoelastic properties of synovial fluid. This improves its lubricating and shock-absorbing functions and reduces mechanical overload of the joint. Clinical trials showed a pain decrease and improvement in joint mobility up to six months.
Ostenil Plus: OSTENIL PLUS also contains mannitol, a free radical scavenger, which helps to stabilise the chains of sodium hyaluronate.