Finil 16 Dosage/Direction for Use

Oral.
Dosage in Hypertension: Adults: The recommended initial dose and usual maintenance dose is 8 mg once daily. The dose may be increased to 16 mg once daily. If blood pressure is not sufficiently controlled after 4 weeks of treatment with 16 mg once daily, the dose may be further increased to a maximum of 32 mg once daily. If blood pressure control is not achieved with this dose, alternative strategies should be considered.
Therapy should be adjusted according to blood pressure response. Most of the antihypertensive effect is attained within 4 weeks of initiation of treatment.
Use in the elderly: No initial dosage adjustment is necessary in elderly patients.
Use in patients with intravascular volume depletion: An initial dose of 4 mg may be considered in patients at risk for hypotension, such as patients with possible volume depletion.
Use in impaired renal function: No initial dosage adjustment is necessary in patients with mild to moderate renal impairment (i.e creatinine clearance 30-80 mL/min/1.73 m² BSA). In patients with severe renal impairment (i.e. creatinine clearance <30 mL/min/1.73 m² BSA), the clinical experience is limited and a lower initial dose of 4 mg should be considered.
Use in impaired hepatic function: Patient with hepatic impairment: Dose titration is recommended in patients with mild to moderate chronic liver disease, and a lower initial dose of 4 mg should be considered. Finil 16 should not be used in patients with severe hepatic impairment and/or cholestasis.
Concomitant therapy: Addition of a thiazide-type diuretic such as Hydrochlorothiazide has been shown to have an additive antihypertensive effect with Finil 16.
Use in black patients: The antihypertensive effect of Candesartan is less in black than non-black patients. Consequently, uptitration of Finil 16 and concomitant therapy may be more frequently needed for blood pressure control in black than non-black patients.
Dosage in Heart Failure: The usual recommended initial dose of Candesartan is 4 mg once daily. Up titration to the target dose of 32 mg once daily or the highest tolerated dose is by doubling the dose at intervals of at least 2 weeks.
Special patient populations: No initial dose adjustment is necessary for elderly patients or in patients with intravascular volume depletion, renal impairment or mild to moderate hepatic impairment.
Concomitant therapy: Finil 16 can be administered with other heart failure treatment, including ACE inhibitors, beta-blockers, diuretics and digitalis or a combination of these medicinal products.
Use in children and adolescents: The safety and efficacy of Finil 16 have not been established in children and adolescents (under 18 years). Finil 16 should be taken once daily with or without food.