Elthrocin Tablet Drug Interactions

Theophylline: Recent studies have shown that the use of erythromycin in patients receiving high doses of theophylline may be associated with an increase in serum theophylline levels and with potential theophylline toxicity. In such cases, the dose of theophylline should be reduced.
Alfentanil: Erythromycins, which are hepatic enzyme inhibitors, may decrease the plasma clearance and prolong the duration of action of alfentanil.
Carbamazepine or Valproic acid: Erythromycins may inhibit carbamazepine and valproic acid metabolism, resulting in increased anticonvulsant plasma concentrations and toxicity.
Chloramphenicol or Lincomycins: Erythromycins may antagonize the effects of chloramphenicol or lincomycins.
Cyclosporine: Erythromycin has been reported to increase cyclosporine plasma concentrations and may increase the risk of nephrotoxicity.
Digoxin: Concurrent use of oral antibiotics may increase serum digoxin concentrations.
Ergotamine: Erythromycin inhibits the metabolism of ergotamine and has been reported to increase the vasospasm associated with ergotamines.
Lovastatin: Concurrent use of lovastatin with erythromycin may increase the risk of rhabdomyolysis.
Midazolam or Triazolam: Concurrent use with erythromycin may decrease the clearance of these medications, increasing the pharmacological effect of midazolam or triazolam.
Ototoxic medications, other: Concurrent use of other ototoxic medications with high-dose erythromycin in patients with renal function impairment may increase the potential for ototoxicity.
Warfarin: Use of erythromycin in patients receiving chronic warfarin therapy may result in increased risk of hemorrhage.