Adults: Mild to moderate infection, 250 mg every 6 hours or 500 mg every 12 hours. In very severe infections, the dosage may be increased to 4 g or more daily in divided doses.
Children: 30 mg/kg/day in divided doses. In very severe infection this may be increased to 50 mg/kg or even 100 mg/kg/day given in 2 or 3 divided doses.
The period of treatment is 6-10 days for upper and lower respiratory tract infections. In cases of infection due to β-haemolytic Streptococci of group A, the treatment should be extended to 10 days, and in cases of Mycoplasma pneumoniae to 10-14 days. Optimum serum levels of erythromycin are attained when Elthrocin is taken in the fasting state or immediately before meals.
Skin Infections: Acne: 1 g/day for 1-2 weeks and 0.5 g/day for minimum of 12 weeks. Impetigo: 1g/day for 10 days. Erysipelas, Phlegmon, Furunculosis, Carbuncles: 2 g/day for 10 days. Erythrasma: 1.5 g/day for 6 days.
Otitis Externa: 1.5 g/day for 6-10 days.
Veneral Infections: Nonspecific urethritis: 1.5 to 2 g/day for 14-21 days.
Syphilis: In patients allergic to penicillin, up to 3 g/day in divided doses for 10-20 days.
Lymphogranuloma Venereum: 1.5 g/day for 8-10 days.
Other Infections: Gingivitis: 1 g / day for 6-10 days. Diphtheria, scarlet fever: 1-1.5 g/day for 10 days.
Trachoma: 1.5 g/day for 21 days.
Prophylaxis: Preoperative: 1 g one hour before the procedure followed by 500 mg six hours later.