Duoflow Overdosage

No data are available with regard to overdosage with DUOFLOW. The following statements reflect the information available on the individual components.
Dutasteride: There is no specific antidote for dutasteride. Therefore, if an overdose is suspected appropriate symptomatic treatment should be initiated.
Tamsulosin: Cases of acute overdose with 5mg tamsulosin have been reported. Acute hypotension (systolic blood pressure 70 mmHg), vomiting and diarrhoea were observed in these patients.
In cases of acute hypotension occurring after overdose with tamsulosin hydrochloride cardiovascular support should be given. Normalisation of blood pressure and heart rate may be accomplished by lying the patient down. If this is inadequate, volume expanders and if necessary, vasopressors can then be administered. Since tamsulosin exhibits strong plasma protein binding, dialysis is unlikely to be of benefit in removing tamsulosin from the body. Vomiting may be induced to reduce absorption. If a large dose has been taken, administration of activated charcoal and osmotic laxatives may be useful.