Duoflow Dosage/Direction for Use

Patients >21 years old (including elderly patients): The recommended dose of DUOFLOW is one capsule daily (0.5 mg/0.4 mg).
DUOFLOW must always be taken with a glass of water, up to 30 minutes after a meal. It must never be taken on an empty stomach. Ideally it should be taken at the same time of the day (this means with the same meal).
The capsules should be swallowed whole and not chewed or opened, as contact with the capsule contents may result in irritation of the oropharyngeal mucosa.
Special dosage instructions: Elderly patients: No age-related dose adjustment is required.
Renal impairment: There is no experience available in patients with renal impairment. DUOFLOW should therefore be used with caution especially in patients with severe renal impairment (creatinine clearance <10ml/ min).
Hepatic impairment: There is no experience available in patients with hepatic impairment. DUOFLOW should be used with caution in patients with mild to moderate hepatic impairment. In patients with severe hepatic impairment, the use of DUOFLOW is contraindicated.
Patients ≤21 years old: DUOFLOW is not indicated in patients ≤21 years old.