Duloxpra Side Effects

Summary of the safety profile: The most commonly reported adverse reactions in patients treated with duloxetine were nausea, headache, dry mouth, somnolence and dizziness. However, the majority of common adverse reactions were mild to moderate; they usually started early in therapy, and most tended to subside even as therapy was continued.
Summary of adverse reactions: Infections and infestations: Uncommon: Laryngitis.
Immune system disorders: Rare: Anaphylactic reaction, hypersensitivity disorder.
Endocrine disorders: Rare: Hypothyroidism.
Metabolism and nutrition disorders: Common: Decreased appetite.
Uncommon: Hyperglycaemia (reported especially in diabetic patients).
Rare: Dehydration, hyponatraemia, SIADH.
Psychiatric disorders: Common: Insomnia, agitation, libido decreased, anxiety, orgasm abnormal, abnormal dreams.
Uncommon: Suicidal ideation, sleep disorder, bruxism, disorientation, apathy.
Rare: Suicidal behaviour, mania, hallucinations, aggression and anger.
Nervous system disorders: Very common: Headache, somnolence.
Common: Dizziness, lethargy, tremor, paraesthesia.
Uncommon: Myoclonus, akathisia, nervousness, disturbance in attention, dysgeusia, dyskinesia, restless legs syndrome, poor quality sleep.
Rare: Serotonin syndrome, convulsion, psychomotor restlessness, extra-pyramidal symptoms.
Eye disorders: Common: Blurred vision.
Uncommon: Mydriasis, visual impairment.
Rare: Glaucoma.
Ear and labyrinth disorders: Common: Tinnitus.
Uncommon: Vertigo, ear pain.
Cardiac disorders: Common: Palpitations.
Uncommon: Tachycardia, supraventricular arrhythmia (mainly atrial fibrillation).
Vascular disorders: Common: Blood pressure increased, flushing.
Uncommon: Syncope, hypertension, orthostatic hypotension, peripheral coldness.
Rare: Hypertensive crisis.
Respiratory, thoracic and mediastinal disorders: Common: Yawning.
Uncommon: Throat tightness, epistaxis.
Rare: Interstitial lung disease, eosinophilic pneumonia.
Gastrointestinal disorders: Very common: Nausea, dry mouth.
Common: Constipation, diarrhoea, abdominal pain, vomiting, dyspepsia, flatulence.
Uncommon: Gastrointestinal haemorrhage, gastroenteritis, eructation, gastritis, dysphagia.
Rare: Stomatitis, haemotochezia, breath odour, microscopic colitis.
Hepato-biliary disorders: Uncommon: Hepatitis, elevated liver enzymes (ALT, AST, alkaline phosphatase), acute liver injury.
Rare: Hepatic failure, jaundice.
Skin and subcutaneous tissue disorders: Common: Sweating increased, rash.
Uncommon: Night sweats, urticaria, dermatitis contact, cold sweat, photosensitivity reactions, increased tendency to bruise.
Rare: Stevens-Johnson Syndrome, angioneurotic oedema.
Very rare: Cutaneous vasculitis.
Musculoskeletal and connective tissue disorders: Common: Musculoskeletal pain, muscle spasm.
Uncommon: Muscle tightness, muscle twitching.
Rare: Trismus.
Renal and urinary disorders: Common: Dysuria, Pollakiuria.
Uncommon: Urinary retention, urinary hesitation, nocturia, polyuria, urine flow decreased.
Rare: Urine odour abnormal.
Reproductive system and breast disorders: Common: Erectile dysfunction, ejaculation disorder, ejaculation delayed.
Uncommon: Gynaecological haemorrhage, menstrual disorder, sexual dysfunction, testicular pain.
Rare: Menopausal symptoms, galactorrhoea, hyperprolactinaemia, postpartum haemorrhage.
General disorders and administration site conditions: Common: Falls, fatigue.
Uncommon: Chest pain, feeling abnormal, feeling cold, thirst, chills, malaise, feeling hot, gait disturbance.
Investigations: Common: Weight decrease.
Uncommon: Weight increase, blood creatine phosphokinase increased, blood potassium increased.
Rare: Blood cholesterol increased.