Co-Diovan Dosage/Direction for Use

Dosage regimen: The recommended dose of Co-Diovan is one tablet per day. When clinically appropriate, either 80/12.5 mg, or 160/12.5 mg.
Co-Diovan 160/12.5 mg may be administered in patients whose blood pressure is not adequately controlled after 4 weeks of treatment by valsartan 160 mg monotherapy. Treatment with Co-Diovan 160/25 mg is limited to those patients who do not show adequate blood pressure reduction with Co-Diovan 160/12.5 mg after at least 4 weeks of treatment.
Co-Diovan should be administered consistently with or without food (see Pharmacology: Pharmacokinetics under Actions).
The maximum daily dose is 320 mg/25 mg.
The maximum antihypertensive effect is seen within 2 to 4 weeks.
Renal or Hepatic Impairment: No dosage adjustment is required for patients with mild to moderate renal impairment (creatinine clearance >30 mL/min). In patients with mild to moderate hepatic impairment without cholestasis, the daily dose of valsartan should not exceed 80 mg (see Precautions).
Patients with severe renal or hepatic impairment, biliary cirrhosis, or cholestasis must not take Co-Diovan (see Contraindications).
Pediatric patients (below 18 years): The safety and efficacy of Co-Diovan have not been established in children below the age of 18 years.