Betacort Cream Overdosage

Symptoms and treatment for overdose and antidote(s): Therapeutic efficacy depends on drug release from the vehicle, solubilization of the drug at the skin surface, and its subsequent percutaneous absorption through the outer barrier layer of the epidermis (stratum corneum) so that it can reach the site of action in the living epidermis and / or the dermis.
Factors influencing product selection include skin hydration, site, severity, age, and whether the lesion is moist or dry as well as potency and strength of the product and the method of application.
Occlusion, whether by oleaginous ointment, by a thin film of polythene, or by tape, promotes increased hydration of the stratum corneum and increased absorption.
Excessive prolonged use of topical corticosteroids can result in suppression of pituitary - adrenal function resulting in secondary adrenal insufficiency which is usually reversible. In such cases appropriate symptomatic, supportive treatment is indicated. Gradual withdrawal of the preparation may be necessary.