Sign Out
Pharmacology: Pharmacodynamics: Mode or Mechanisms of Action: Betamethasone diffuses across cell membranes and complexes with specific cytoplasmic receptors. These complexes then enter the cell nucleus, bind to DNA (chromatin), and stimulate transcription of messenger RNA (mRNA) and subsequent protein synthesis of various enzymes thought to be ultimately responsible for anti-inflammatory effects of topical application of adrenocorticoids.
Pharmacokinetics: Absorption: Absorbed systemically. Occlusion, use over extensive areas, or prolonged used increases absorption of topical dosage forms.
Rectal absorption is increased if intestinal mucosa is inflamed.
Metabolism: Mostly in skin, fluorinated compounds more slowly metabolised in the skin and thus tend to be systemically absorbed to a greater extent.
Half-life: Unbound hydrocortisone-Approximately 2 hours.
