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Contraindicated in patients with severe renal impairment or renal failure, hypernatremia, metabolic or respiratory alkalosis, hypocalcaemia, hypochlorhydria, Addison's disease, acute dehydration, heat cramps, overt and occult cardiac failure and severe myocardial damage.
Not recommended in concomitant use with hexamine mandelate or hexamine hippurate therapy because an acidic urine is needed.
Avoid concomitant use with quinolone antibiotics as to prevent crystalluria in alkaline urine.
