Ampholip Adverse Reactions

Patients in whom significant renal toxicity was observed following conventional Amphotericin B frequently did not experience similar effects when Ampholip was substituted. Adverse reactions related to the administration of Ampholip have generally been mild or moderate, and have been most prevalent during the first 2 days of dosing.
Premedication (e.g. paracetamol) may be administered for the prevention of infusion related adverse events. The most common clinical adverse effects have been chills, fever, nausea and vomiting, which may occur during the first 2 days of treatment.
Decline in renal function, shown by increased serum creatinine, azotemia and hypokalaemia, have not typically required discontinuation of treatment. Ampholip has not been reported to directly cause changes in hepatic or haematologic function.
Adverse reaction that have been reported to occur with conventional Amphotericin B may occur with Ampholip. In general, the physician should monitor the patient for any type of adverse event associated with conventional Amphotericin B.
Metabolism and nutrition disorders: Frequency "common": Hyperkalaemia.
Adverse reaction including fever chills and rigors may occur. Anaphylactoid reactions including hypotension, tachycardia bronchospasm, dyspnoea , hypoxia and hyperventilation have also been reported.