Ampholip Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Amphotericin B (lipid complex)

Indications/Uses

Severe systemic &/or deep mycoses in cases where toxicity or renal failure precludes use of conventional amphotericin B in effective doses & where prior systemic antifungal therapy has failed. Disseminated candidiasis & aspergillosis; severely neutropenic patients.

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Dosage/Direction for Use

Adult & childn 5 mg/kg single IV infusion at 2.5 mg/kg/hr.

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Overdosage

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Contraindications

Hypersensitivity.

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Special Precautions

Not intended for common or superficial, clinically inapparent fungal infections diagnosed only by +ve skin or serological tests. Hyperkalaemia. Monitor renal function & serum K prior to & during therapy. Not to be diluted w/ saline soln or mix w/ other drugs or electrolytes. Not to be used w/ in-line filter. Concomitant use w/ hepatotoxic drugs; patients receiving nephrotoxic drugs; K supplementation in patients w/ previous hypokalaemia. Renal impairment, pre-existing renal disease. Pregnancy & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Chills, fever, nausea, vomiting; increased serum creatinine, azotemia, hypokalaemia; hyperkalaemia; rigors, anaphylactoid reactions eg, hypotension, tachycardia, bronchospasm, dyspnoea, hypoxia, hyperventilation.

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Drug Interactions

Closely monitor renal & haematologic function w/ concomitant use of zidovudine. Increased serum creatinine w/ high-dose cyclosporin. Enhanced toxicity of flucytosine. Concomitant use w/ antineoplastics, corticosteroids, ACTH, antiarrhythmics, digitalis glycosides, skeletal muscle relaxants. Monitor renal function w/ concomitant use of nephrotoxic drugs.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Ampholip detailed prescribing information

Storage

View Ampholip storage conditions for details to ensure optimal shelf-life.

Description

View Ampholip description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Antifungals

ATC Classification

J02AA01 - amphotericin B ; Belongs to the class of antibiotics. Used in the systemic treatment of mycotic infections.

Regulatory Classification

Presentation/Packing

Form

Ampholip susp for inj 50 mg/10 mL

Packing/Price

10 mL x 1's

Ampholip

amphotericin b

Manufacturer:

Bharat Serums & Vaccines

Distributor:

Pahang Pharmacy