Ulcetra Drug Interactions

Concomitant Use with MAO Inhibitor and Serotonin Reuptake Inhibitor: Interactions with MAO inhibitors have been reported for some drugs that work centrally (in the central nervous system).
Use with Carbamazepine: Co-administration between Tramadol hydrochloride and carbamazepine leads to a significant increase in Tramadol metabolism. Patients taking carbamazepine may be significantly lessen the analgesic effect of Tramadol Ulcetra component.
Usage with Quinidine: Tramadol is metabolized into M1 by CYP2D6. Co-administration of quinidine and Tramadol resulted in increased concentrations of Tramadol. The clinical consequences of these findings are unknown.
Co-administration with Warfarin-like Compounds: In order to be medically correct, periodic evaluation of prothrombin time should be made if Ulcetra and these drugs are administered concomitantly due to reports of an increase in INR in some patients.
Use with CYP2D6 Inhibitor: The study of in-vitro drug interactions on human liver microsomes showed that concomitant administration with CYP2D6 inhibitors such as fluoxetine, paroxetine, and amitriptyline could lead to inhibition of Tramadol metabolism.
Use with Cimetidine: Co-administration Ulcetra with cimetidine has not been studied. Co-administration of Tramadol with cimetidine did not result in clinically significant changes in Tramadol pharmacokinetics.