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Overdosage leads to hypothyroidism with corresponding symptoms of a reduced metabolism and through the feedback effect, to activation of the anterior pituitary lobe with subsequent goiter growth. This can be avoided by dose reduction as soon as a euthyroid metabolic condition is achieved and, if necessary, by additional administration of levothyroxine (see Dosage & Administration).
Negative consequences of accidental ingestion of high doses of thiamazole are not known.
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