Thyrozol Dosage & Drug Information

Concise Prescribing Info Bahasa Concise Prescribing Info Full Prescribing Info Contents Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Side Effects Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Thiamazole

Indications/Uses

Listed in Dosage.

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Dosage/Direction for Use

Adult Conservative treatment of hyperthyroidism: Complete thyroid hormone blockade production Initially 25-40 mg daily. Max daily dose: 40 mg in single dose of 20 mg max. Mild cases: 10 mg twice daily. Severe cases: 20 mg twice daily. Maintenance: Reduce dose to 5-20 mg daily (usually requires additional administration of thyroid hormones). 2nd dosage regimen: Monotherapy Usually 2.5-10 mg daily. Prep for surgery in all forms of hyperthyroidism Attain normal metabolic activity of thyroid gland. Perform surgery as soon as this is achieved. Otherwise, administer supplementary thyroid hormones. In the last 10 days before surgery, iodine may be administered to consolidate the thyroid tissue. Treatment before radioiodine therapy Attain normal metabolic activity of thyroid gland. Higher radioiodine doses may be necessary. Childn Initially 0.3-0.5 mg/kg/day. Maintenance: 0.2-0.3 mg/kg/day. Additional thyroid hormone treatment may be required. Pregnant women 2.5-10 mg daily w/o thyroid hormone. Patient w/ liver damage Low dose as possible.

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Overdosage

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Administration

Should be taken with food.

Contraindications

Hypersensitivity. Granulocytopenia, cholestasis existing before start of therapy, previous damage to bone marrow after treatment w/ carbimazole or thiamazole.

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Special Precautions

Avoid long-term treatment & monitor patients w/ large goitres. Agranulocytosis; monitor blood count. Discontinue treatment if bone marrow damage occurs. Reduce dose once a eurothyroid metabolic condition is achieved. Goitre growth under therapy; rare hereditary galactose intolerance, lactase deficiency or glucose-galactose malabsorption. Pregnancy & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Frequently, allergic skin reactions. Nausea, vomiting, epigastric distress, arthralgia, paresthesia, taste loss, alopecia, myalgia, headache, pruritus, drowsiness, neuritis, edema, vertigo, skin pigmentation, jaundice, sialadenopathy & lymphadenopathy.

Drug Interactions

Anticoagulant effect are potentiated by vit K.

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Storage

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Action

View Thyrozol mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Antithyroid Agents

ATC Classification

H03BB02 - thiamazole ; Belongs to the class of sulfur-containing imidazole derivative agents. Used in the management of thyroid diseases.

Regulatory Classification

Presentation/Packing

Form

Thyrozol FC tab 10 mg

Packing/Price

100's (Rp367,670/pak)

Form

Thyrozol FC tab 5 mg

Packing/Price

100's (Rp247,480/pak)

Thyrozol

thiamazole

Manufacturer:

PT. Merck Tbk