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Action Mechanism: The depth of anesthesia changes rapidly following changes in the inspired concentration of Sevoflurane. Emergence and recovery are particularly rapid. Therefore, patients may require early post-operative pain relief. As with all other inhalation agents, Sevoflurane depresses cardiovascular function in a dose related fashion. Increases in Sevoflurane concentration resulted in decrease in mean arterial pressure, but there was no change in heart rate. Sevoflurane did not alter plasma or adrenaline concentrations. No evidence of seizures was observed. In patients with normal intracranial pressure (ICP), Sevoflurane had minimal effect on ICP and preserved CO2 responsiveness.
The safety of Sevoflurane has not been investigated in patients with a raised ICP in patients at risk for elevations of ICP, Sevoflurane should be administered cautiously conjunction with ICP reducing maneuvers such as hyperventilation.
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