Sanmeto Special Precautions

Reduced dosages are recommended in patients with renal failure, since the risk of extrapyramidal effects may increase.
Patients undergoing treatment with this drug should not take charge of vehicles or machineries.
It should be given with caution in patients taking other drugs that can also cause extrapyramidal reactions, such as phenothiazines.
It should be used with caution in nursing mothers because Metoclopramide Hydrochloride is excreted in breast milk.
Injection: Metoclopramide Hydrochloride should not be used during the first trimester of pregnancy. In the subsequent period of pregnancy, the use of the drug should be limited only in those cases of clear symptom where an alternative intervention would not be possible, thus excluding the frequent and simple cases of vomiting of pregnancy and prevention of same.
Tablet: It is not recommended to be used anticholinergic drug concomitantly.