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Exemestane given up to 800 mg in single dose to healthy female and up to 600 mg daily to post-menopausal women with advanced breast cancer were well tolerated. The single dose of Exemestane that could result in life-threatening symptoms is not known. In rats and dogs, lethality was observed after single oral doses equivalent respectively to 2000 and 4000 times the recommended human dose on mg/m2 basis.
There is no specific antidote to overdose and treatment must be symptomatic. General supportive care, including frequent monitoring of vital signs and close observation of the patients, is indicated.
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