Nateran Dosage & Drug Information

Concise Prescribing Info Bahasa Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Exemestane

Indications/Uses

Advanced breast cancer in women w/ natural or induced post-menopausal status whose disease has progressed following anti-oestrogen therapy. Adjuvant treatment of post-menopausal women w/ estrogen-receptor +ve early breast cancer, following 2-3 yr of initial adjuvant tamoxifen therapy.

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Dosage/Direction for Use

Adult & elderly 25 mg once daily. Patient w/ advanced breast cancer Continue until tumor progression is evident. Patient w/ early breast cancer Continue until completion of 5 yr of adjuvant endocrine therapy or until local or distant recurrence or new contralateral breast cancer.

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Overdosage

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Administration

Should be taken with food.

Contraindications

Hypersensitivity. Pre-menopausal women. Pregnancy & lactation.

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Special Precautions

Not to be administered to women w/ pre-menopausal endocrine status. Assess LH, FSH & oestradiol levels to ascertain post-menopausal status; bone mineral density of women w/ osteoporosis or at risk of osteoporosis at commencement of treatment. Reductions in bone mineral density. Consider routine assessment of 25 hydroxy vit D levels prior to treatment. Supplementation of vit D in women w/ vit D deficiency. May impair ability to drive or operate machinery. Not be administered to lactating woman. Not recommended in childn.

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Use In Pregnancy & Lactation

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Adverse Reactions

Depression, insomnia; headache, dizziness; hot flushes; abdominal pain, nausea; increased hepatic enzyme, blood bilirubin & blood alkaline phosphatase; increased sweating; joint & musculoskeletal pain; pain, fatigue. Anorexia; carpal tunnel syndrome; vomiting, diarrhoea, constipation, dyspepsia; alopecia, rash; fracture, osteoporosis; peripheral oedema, asthenia. Paraesthesia; urticaria, pruritus.

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Drug Interactions

Concomitant use w/ drugs metabolized via CYP3A4 & w/ narrow therapeutic window. Negated pharmacological action w/ oesterogen-containing medicines. Reduced efficacy w/ rifampicin, anticonvulsants (eg, phenytoin & carbamazepine) & herbal prep containing Hypericum perforatum (St. John's wort).

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Nateran detailed prescribing information

Storage

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Description

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Action

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MIMS Class

Cancer Hormone Therapy

ATC Classification

L02BG06 - exemestane ; Belongs to the class of enzyme inhibitors. Used in treatment of neoplastic diseases.

Regulatory Classification

Presentation/Packing

Form

Nateran FC tab 25 mg

Packing/Price

3 × 10's

Nateran

exemestane

Manufacturer:

Fahrenheit Synthon