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Tab: Other depressant drugs such as tranquilizer, sedatives, hypnotics, alcohol MAO inhibitors. Tranquilizers, mostly, phenothiazines, which work antagonists against opiate analgesic agents. Dextroamphetamine might inhibits the analgesic effects of opiate agonist.
SR tab: Concurrent administration of monoamine oxidase inhibitors or within two weeks of discontinuation of their use is contraindicated. The concomitant use of other central nervous system depressants including sedatives or hypnotics, general anesthetics, phenothiazines, tranquilizers, and alcohol may produce additive depressant effects. Morphine Sulfate Pentahydrate Tablets may enhance the neuromuscular blocking action of skeletal muscle relaxants and produce an increased degree of respiratory depression. Interactive effects resulting in respiratory depression, hypotension, profound sedation, or coma may result if these drugs are taken with the usual doses of morphine.
Syr: Antagonistic effect with other depressant drugs such as tranquilizers mostly phenothiazines, sedatives, hypnotics, alcohol, MAOIs. May inhibit analgesic effect of opiate agonists with dextroamphetamine. MAOIs, gabapentin, ritonavir, rifampicin, cimetidine, tranquilizers such as benzodiazepine & related drugs, CNS depressant. May increase plasma esmolol concentration. Domperidone and metoclopramide. Oral P2Y12 inhibitor antiplatelet treatments. May delay mexiletine absorption. Phenothiazine antiemetic drugs.
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