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Tab: Prevalent dose: 10-30 mg/4 hours as needed.
Individual dose depends on the severity of pain according to doctor's instructions. Adults and >13 years: Conventionally 5-20 mg taken every 4 hours, the doses are individualized depends on the severity of pain, the patient's response and the effects of previous analgesics. Children 1-5 years: 5 mg every 4 hours (Maximum: 30 mg daily); 6-12 years: 5-10 mg every 4 hours (Maximum: 60 mg daily).
The doses are individualized depends on the severity of pain, the patient's response and the effects of previous analgesics.
SR tab: Morphine Sulfate tablets must swallowed whole and not chewed, broken or crushed.
Taking broken, chewed or crushed Morphine Sulfate Pentahydrate tablets could lead to the rapid release and absorption of a potentially toxic dose of morphine.
Morphine Sulfate Pentahydrate tablets are intended for use in patients who require more than several days continuous treatment with a potent opioid analgesic.
A patient presenting with severe pain uncontrolled by weaker opioid should normally be started on 30 mg Morphine Sulfate Pentahydrate tablets 12 hourly increasing to 60 mg 12 hourly when required. If higher doses are necessary they should be made in 25%-50% increments.
Morphine Sulfate Pentahydrate tablets should be used twice daily, at 12 hourly intervals. The dosage is dependent upon the severity of the patient's previous history of analgesic requirements.
A patient presenting with severe pain should normally be started on dosage of one or two Morphine Sulfate Pentahydrate 10 mg tablets twice daily. Increasing severity of pain or tolerance to morphine will require increased dosage of Morphine Sulfate Pentahydrate tablets using 10 mg, 30 mg, 60 mg and 100 mg tablets alone or in combination to achieve the desired relief. A patient transferred from other oral morphine preparations normally receive the same total twenty-four hour morphine dosage divided between morning and evening administration. Patients receiving Morphine Sulfate Pentahydrate tablets in place of parenteral morphine should be given a sufficiently increased dosage to compensate for any reduction in analgesic effects associated with oral administration. Usually such increases requirement is of the order of 50% to 100%. In such patients individual dose adjustment are required.
Post-Operative Pain: Morphine Sulfate Pentahydrate Tablet are recommended in the first 24 hours post-operatively; thereafter it is suggested that the following dosage schedule be observed at the physician discretion.
a. Morphine Sulfate Pentahydrate 20 mg Tablets 12 hourly to patients under 70 kilograms.
b. Morphine Sulfate Pentahydrate 30 mg Tablets 12 hourly to patients over 70 kilograms.
Supplemental parenteral morphine may be given if required, but with careful attention to the total dosage of morphine and bearing in mind the prolonged effects of morphine in the Morphine Sulfate Pentahydrate formulation.
As with all oral morphine preparations, Morphine Sulfate Pentahydrate tablets should be used with caution postoperatively, and particularly in "acute abdomen" and following abdominal surgery.
Syr: Adults: 1-2 teaspoon (10-20 mg) 4 hourly. Maximum daily dose: 120 mg.
Children 13-18 years: ½-2 teaspoon (5-20 mg) 4 hourly, maximum daily dose: 120 mg.
Children 6-12 years: ½-1 teaspoon (5-10 mg) 4 hourly, maximum daily dose: 60 mg.
Children: 2-5 years: ½ teaspoon (5 mg) 4 hourly, maximum daily dose: 30 mg.
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