Patients with history of atopy or severe anaphylaxis to allergens, first-degree heart block, heart failure, orthostatic hypotension, severe peripheral circulatory disturbance or disorders (e.g. severe forms of Raynaud's syndrome), mild or moderate chronic obstructive pulmonary disease, diabetes (especially labile diabetes), hyperthyroidism, corneal diseases, other types of glaucoma (e.g. inflammatory, neovascular or chronic angle-closure glaucoma, open-angle glaucoma of pseudophakic patients, pigmentary glaucoma), closed-angle glaucoma (as monotherapy), history of herpetic keratitis, active intraocular inflammation; aphakic patients, pseudophakic patients with torn posterior lens capsule, risk factors for macular oedema; myasthenia gravis. Patients undergoing surgery.