Reactive airway disease (e.g. existing or history of bronchial asthma, severe chronic obstructive pulmonary disease); sinus bradycardia, sick sinus syndrome, sino-atrial block, second- or third-degree atrioventricular block (not controlled with a pacemaker), overt cardiac failure, cardiogenic shock; active herpes simplex keratitis or history of recurrent herpetic keratitis specifically associated with prostaglandin analogues.