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It is recommended to use metronidazole as single drug. In combination with other antibiotic, both should be given in a full dose for normal therapy.
Concomitant use with warfarin and coumarin anticoagulant: prolonged prothrombin time should be considered and reduce the anticoagulant dose if necessary.
Cimetidine might prolong metronidazole plasma clearance which leads to toxic concentration of metronidazole.
Psychotic reaction has been reported when concomitant metronidazole, disulfiram and alcohol was taken simultaneously.
Metronidazole reduces the clearance of 5-fluorouracil and can therefore result in increased toxicity of 5-fluorouracil.
Plasma levels of busulfan may be increased by metronidazole which may lead to severe busulfan toxicity.
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