Patients who can't receive oral therapy. Not indicated for mild gastrointestinal complaints, ie. nervous dyspepsia. Rule out any possibility of a diagnosis of malignant gastric ulcer or esophageal malignancy prior treatment. In elderly and patients with impaired kidney function, dosage should not exceed 40 mg daily. Dosage should be adjusted to 20 mg in patients with severe liver dysfunction. Prothrombine time should be monitored in patients who are receiving concomitant therapy with coumarin anticoagulants. Children. Pregnancy, lactation.