Farpresin Special Precautions

General: Vasopressin should be used cautiously in the presence of epilepsy, migraine, asthma, heart failure, renal failure or any state in which a rapid addition to extracellular water may produce hazard for an already overburdened system.
Information for Patients: Side effects such as blanching of skin, abdominal cramps, and nausea may be reduced by taking 1 or 2 glasses of water at the time of vasopressin administration.
Laboratory Tests: Electrocardiograms (ECG) and fluid and electrolyte status determinations are recommended at periodic intervals during therapy.
This drug should not be used in patients with vascular disease, especially disease of the coronary arteries except with extreme caution.
In such patients, even small doses may precipitate anginal pain, and with larger doses, the possibility of myocardial infarction should be considered. Vasopressin may produced water intoxication.
The early signs of drowsiness, listlessness and headaches should be recognized, to prevent terminal coma and convultions.
Special care should be taken to avoid extravascular tissue infiltration at the infusion site. The intense vasoconstriction may lead to local necrosis and sloughing.