Cetrotide Special Precautions

During or following ovarian stimulation an ovarian hyperstimulation syndrome can occur. This event must be considered as an intrinsic risk of the stimulation procedure with gonadotropins.
An ovarian hyperstimulation syndrome should be treated symptomatically eg, with rest, IV electrolytes/colloids and heparin therapy.
Luteal phase support should be given according to the reproductive medical centre's practice.
There is limited experience up to now with the administration of Cetrotide during a repeated ovarian stimulation procedure. Therefore, Cetrotide should be used in repeated cycles only after a careful risk/benefit evaluation.
Effects on the Ability to Drive or Operate Machinery: Due to its pharmacological profile, cetrorelix is unlikely to impair the patient's ability to drive or to operate machinery.
Use in pregnancy & lactation: Cetrotide is not intended to be used during pregnancy and lactation (see Contraindications).
Studies in animals have indicated that cetrorelix exerts a dose related influence on fertility, reproductive performance and pregnancy. No teratogenic effects occurred when the drug was administered during the sensitive phase of gestation.