Binosto Drug Interactions

If taken at the same time, it is likely that food and beverages (including mineral water), calcium supplements, antacids, and some oral medicinal products will interfere with absorption of alendronate. Therefore, patient must wait at least 30 minutes after taking alendronate before taking any other oral medicinal product (see Dosage & Administration and Pharmacology: Pharmacokinetics under Actions).
In healthy subjects, oral prednisone (20 mg there times daily for five days) did not produce a clinically meaningful change in oral bioavailability of alendronate (a mean increase ranging from 20% to 44%).
No other interactions with medicinal products of clinical significance are anticipated. A number of patients in the clinical trials received oestrogen (intravaginal, transdermal, or oral) while taking alendronate. No adverse experiences attributable to their concomitant use were identified.
Since NSID use is associated with gastrointestinal irritation, caution should be used during concomitant use with alendronate.
Although otherwise specific interaction studies were nor performed, in clinical studies alendronate was used concomitantly with a wide range of commonly prescribed medicinal products without evidence of clinical adverse interactions.