3TC Adverse Reactions

The following events have been reported during therapy for HIV disease with 3TC alone and in combination with other anti-retroviral agents. With many still unclear whether they are related to the medicinal products or are as a result of the underlying disease process.
The following convention has been utilized for the classification of undesirable effects: Very common (>1/10); common (>1/100, <1/10); uncommon (>1/1000, <1/100); rare (>1/10,000, <1/1000); very rare (<1/10,000).
Blood and Lymphatic Systems Disorders: Uncommon: Neutropenia, anemia, thrombocytopenia. Very Rare: Pure red cell aplasia.
Metabolism and Nutrition Disorders: Common: Hyperlactatemia. Rare: Lactic acidosis (see Precautions).
Redistribution/Accumulation of Body Fat (see Precautions): The incidence of this event is dependent on multiple factors including the particular antiretroviral drug combination.
Nervous System Disorders: Common: Headache. Very Rare: Paresthesia. Peripheral neuropathy has been reported although a causal relationship to treatment is uncertain.
Gastrointestinal Disorders: Common: Nausea, vomiting, upper abdominal pain, diarrhea. Rare: Pancreatitis, although a causal relationship to treatment is uncertain. Rises in serum amylase.
Hepatobiliary Disorders: Uncommon: Transient rises in liver enzymes (AST, ALT).
Skin and Subcutaneous Tissue Disorders: Common: Rash, alopecia.
Musculoskeletal and Connective Tissue Disorders: Common: Arthralgia, muscle disorders. Rare: Rhabdomyolysis.
General Disorders and Administration Site Conditions: Common: Fatigue, malaise, fever.