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Neutropenia and Diarrhea: Severe or life threatening neutropenia may occur. Withhold TRODELVY for absolute neutrophil count below 1500/mm3 or neutropenic fever. Monitor blood cell counts periodically during treatment. Consider G-CSF for secondary prophylaxis [see Dose Modifications for Adverse Reactions under Dosage & Administration]. Initiate anti-infective treatment in patient with febrile neutropenia without delay [see Neutropenia under Precautions].
Severe diarrhea may occur. Monitor patients with diarrhea and give fluid and electrolytes as needed. At the onset of diarrhea, evaluate for infectious causes and, if negative, promptly initiate loperamide [see Diarrhea under Precautions]. If severe diarrhea occurs, withhold TRODELVY until resolved to ≤Grade 1 and reduce subsequent doses [see Dose Modifications for Adverse Reactions under Dosage & Administration].
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