Tanakan Mechanism of Action

Pharmacology: Vasoregulating action on vascular system; Rheological effects, mainly anti-PAF (Platelet Activating Factor) and anti-sludge properties; Protective effect on cellular metabolism; Improvement in neurotransmission; Free radical scavenging and anti-ischaemic effects.
Pharmacokinetics: The active ingredient is standardized Ginkgo biloba extract titrated at 24% with heterosides of Ginkgo and 6% of di and sesquiterpene (ginkgolides A, B and C bilobalide).
In man, only the pharmacokinetic parameters of the terpenic fraction have been highlighted.
The ginkgolides A and B and the bilobalide have an oral bioavailability of 80 to 90%. Maximum concentration is reached in 1 to 2 hours; the elimination half-lives last for around 4 hours (bilobalide, ginkgolide A) to 10 hours (ginkgolide B). These substances are not broken down in the body and they are principally eliminated in the urine, and a small quantity excreted in the stools.