Pinaverium bromide: Uses, Dosage, Side Effects and...

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Hong Kong prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Functional disorders of biliary tract, Irritable bowel syndrome

Adult: For treatment and relief of symptoms: Initially, 50 mg tid; may increase to 100 mg tid if necessary.

Administration

Pinaverium bromide Should be taken with food. Swallow the tablet whole with a glass of water in the middle of a meal, do not chew, crush, or suck the tablet. The tablet should not be swallowed when in lying position or just before bedtime.

Special Precautions

Patient with possible gastroesophageal reflux or hiatal hernia, pre-existing oesophageal lesion. Not indicated for the relief of motility dysfunction associated with underlying disease states. Pregnancy and lactation.

Adverse Reactions

Significant: Oesophageal irritation.
Gastrointestinal disorders: Abdominal pain, constipation, dry mouth, dyspepsia, nausea, diarrhoea, vomiting.
General disorders and administration site conditions: Asthenia.
Nervous system disorders: Headache, somnolence.
Skin and subcutaneous tissue disorders: Rash, pruritus, urticaria, erythema.

Overdosage

Symptoms: Nausea, flatulence, and diarrhoea.

Management: Symptomatic and supportive treatment.

Drug Interactions

Enhanced spasmolysis with anticholinergic agents.

Action

Description:
Overview: Pinaverium is a calcium channel blocker, antispasmodic agent.
Mechanism of Action: Pinaverium inhibits calcium influx through voltage-sensitive channels in the gastrointestinal smooth muscle cells, leading to a spasmolytic effect in the gut.
Pharmacokinetics:
Absorption: Poorly absorbed. Bioavailability: <1%. Time to peak plasma concentration: Within 1 hour.
Distribution: Plasma protein binding: 97%.
Metabolism: Metabolised in the liver via demethylation and hydroxylation.
Excretion: Via faeces. Elimination half-life: Approx 1.5 hours.

Chemical Structure

Storage

Store below 30°C. Protect from light.

MIMS Class

Antispasmodics

ATC Classification

A03AX04 - pinaverium ; Belongs to the class of other drugs used for functional bowel disorders.

References

Brayfield A, Cadart C (eds). Pinaverium Bromide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 02/10/2025.

Dicetel (Abbott Laboratories [M] Sdn Bhd). MIMS Malaysia. http://www.mims.com/malaysia. Accessed 02/10/2025.

Dicetel 100 mg Film-coated Tablet (Abbott Laboratories [M] Sdn Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 02/10/2025.

Pinaverium. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 02/10/2025.

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