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Secondary hyperparathyroidism in patients on maintenance dialysis: The usual starting dosage for adults is 1 mg of evocalcet administered orally once daily. The starting dose may be 2 mg once daily, depending on the patient's condition. The subsequent oral dose is adjusted within the range from 1 to 8 mg once daily while parathyroid hormone (PTH) and serum calcium levels of the patient are closely monitored. The dose may be increased up to 12 mg once daily if the patient has an inadequate response.
Hypercalcaemia in patients with parathyroid carcinoma and hypercalcaemia in patients with primary hyperparathyroidism who are unable to undergo parathyroidectomy or patients with recurrent primary hyperparathyroidism after parathyroidectomy: The usual starting dosage for adults is 2 mg of evocalcet administered orally once daily. The starting dose may be 2 mg twice daily depending on the serum calcium levels of the patient. The subsequent oral dose is adjusted depending on the serum calcium levels of the patient, and may be increased to a maximum of 6 mg 4 times daily.
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