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Overdose leading to fat overload syndrome may occur when the triglyceride level during lipid infusion rises >3 mmol/L, acutely, as a result of too rapid infusion rate or chronically at recommended rates of infusion in association with a change in the patient's clinical condition eg, renal function impairment or infection.
Overdosage may lead to side effects (see Adverse Reactions).
In these cases, the lipid infusion should be stopped or, if necessary, continued at a reduced dosage. The administration of fat also has to be stopped if a marked increase in blood glucose levels occur during infusion of Omegaven. A severe overdosage of Omegaven without simultaneous administration of a carbohydrate solution may lead to metabolic acidosis.
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